Projects

At ADI Biosolution, we believe to enhance the life science research in various aspects like Drug Development, Functional Analysis of complex high-throughput data, and resource and application development for analysis of Complex Biological Problems with accurate results and all these must be based on a fundamental understanding of human biology and computer technologies. That means drawing on the unparalleled resource of our one-of-a-kind, manually curated genomics and Proteome database and analysis software’s / servers which are able to perform integrated and comparative analysis of multiple data types using advanced algorithms derived from an in-depth understanding of Molecular Biology and Human Physiology.

Our expert team of Molecular Biologists, Biostatisticians, Biotechnologists, Bioinformaticians and Software Engineers working together on different Bioinformatics projects (Databases & Software’s). We use various Technologies for Development such as ASP.NET, Java, PERL-CGI, PHP and projects are characterized by an intuitive interface.

In short, rigorous and robust Chemoinformatics, Proteomics and Genomics Databases and Bioinformatics Software’s are required.

Intein InfoBase is a brand-new database of all kinds of inteins. The distinguished features of the database are:

• A new classification system has been introduced based on the families to which an intein belong.
• Intein InfoBase also provides an efficient search option, allowing recovery of sequence, related publications and other information.
• The Intein InfoBase has an advance search engine and several tools for the analysis of inteins

The Lipocalins are a family of proteins which transport small hydrophobic molecules such as steroids, bilins, retinoid, and lipids. They share limited regions of sequence homology and common tertiary structure architecture. This is an eight stranded antiparallel beta-barrel with a repeated + 1 topology enclosing an internal ligand binding site. These proteins are found in gram negative bacteria, vertebrate cells, and invertebrate cells, and in plants. Lipocalins have been associated with many biological processes, among them immune response, pheromone transport, biological prostaglandin synthesis, retinoid binding, and cancer cell interactions. The Lipocalins were once regarded as a eukaryotic protein family, but new members have been recently discovered in bacteria.

Leugenbase (LGD) is a comphersnsive database of genes related to different types of leukemia. Leugenbase covers 15 different types of Leukemia. Leugen Database consits 555 entries, each entry in database having 33 parameters.

The Most Comprehensive Source for Molecular Information’s for Gene, Target and Biomarkers for Human Disease.

The GeTBio provides you in depth knowledge of the Human Disease, their related Genes and Biomarkers, with the 2D and 3D structure of Target Proteins generated by employing Advanced Computational Technologies. Our GeTBio research team continually monitors different sources for primary and experimental data collection and analyzed the data in different ways to get the particular information’s to provide the most detailed information arrangement for the various human disease with their Genes, Targets and Biomarkers world wide to the pharmaceutical industry. Our clients use this leading edge service to be most excellent in the early age drug development in their competitive market place.

P-Pro-X is a Protein Property Explorer which predicts the properties of protein like hydropathicity and enable the user to predict the location of the input protein sequence. It is found significant in exploring the localization of a hypothetical protein sequences that are useful for various lifescience projects. The unique properties of amino acids are the basis of these predications.

The Tool is developed in ADI Biosolution Lab. as a part of project that is based upon PERL Programming, CGI & HTML interface.

• The tool works on the basis of the hydrophobic scale proposed in 1982 by Jack Kyte and Russell F. Doolittle.
• Tt works well on raw amino acid sequence

•  tool predicts the properties of protein like hydropathicity and enable the user to predict the location of the input protein sequence.
• It enables the user to information like individual amino count, overall sequence length of input query sequence

MolyQul is a molecular property prediction server that lets you draw chemical structures and calculates drug-relevant properties (Molecular formula, Molecular Weight, Hydrogen bond donors and acceptors, solubility, volume, charge, LogP, helping to predict violations to Lipinski`s rule of five) of a valid structure. MolyQul uses many algorithms and methods to precisely predict the chemical properties. In addition MolyQul provides an exceptional feature where user can give input in the form of a text file in MDL mol format. MolyQul is product of ADI Biosolution.

MolyQul Server is free to academics and educational institutions for non-commercial use and can be access through the company`s secure server using the Internet. MolyQul is free to support internet research community and to provide a test bench for our tools.

• MolyQul empowers a chemist or a biologist to draw any valid chemical structure to calculate drug-relevant properties.
• MolyQul provides an exceptional feature where user can give input in the form of a text file in MDL mol format.
• User can give input through any of the medium i.e. by drawing chemical structure or through text file in MDL mol format. SMILES calculation is not feasible when the user submits the molecule via text file.
• User can resubmit a molecular structure via JME even when first input is given in text format.

• Application for research in pharma industry and life science research community.
• The MolyQul server is a powerful tool that will provide users to calculate drug-relevant properties with accuracy.

STABIlity PREDictor is a web based application that had drawn its inspiration from the recent studies demonstrating the role of GC residues in the genome. It scans the input sequence  for the Guanine and Cytosine residues and predicts out the GC Content along with length and the other nucleotide bases present in the given sequence.

• The Guanine-Cytosine .i.e. GC content is defined as the percentage of G’s and C’s of the total bases in the provided input sequence. In usual cases GC content of primers is found to lie between 40-60% are responsible for the better binding results of template-primer.
• These unique G-C bonds have enormous contribution towards the stability (increased Tm) of potential template-primer bindings as compared to lesser stable A=T hydrogen bonds. Moreover it has been found that two primer/template complexes with identical GC content can have different melting temperatures because base order influences the overall stability.

• GC content has direct correlation with the stability of the genome.
• Prediction of extent of  template-primer bindings

MolTracer is a web based server for prediction of residues in a protein structure, which are closest to a specified point around it. There is lots of tools and software’s, which can be used to compute distance between two points by clicking on them. This manual interpretation is prone to error. Therefore a need of such a tool was eminent that could precisely compute the distance between points and give a sorted output to remove all discrepancies of the present method of performing all these operations manually. MolTracer is product of ADI Biosolution, a division of ADI Group.

MolTracer is free to academics and educational institutions for non-commercial use and can be access through the company`s secure server using the Internet. MolTracer is free to support internet research community and to provide a test bench for our tool.

• MolTracer is designed to lend helping hand to researchers; who now will not have to spend their time on the hit and trial method of clicking on different residues to draw conclusions about the closest one.

• MolTracer analyzes protein file and pocket file/point co-ordinates given by the user to compute the distance, and then display the residues that are in the proximity of the given spatial co-ordinate according to the input.
• MolTracer empowers research community to locate the closest atom to the binding pocket.
• MolTracer is developed using PERL-CGI technology.

• Application for research in pharma industry and in Life science research community.
• The MolTracer server is a powerful tool that will provide users to calculate closest atom to a binding pocket with accuracy.